Grant to help pave a big data highway to explore genome, enhance health By Matt Swayne February 14, 2017 UNIVERSITY PARK, Pa. — A $6.1 million, five-year grant from the National Institute of Diabetes, Digestive and Kidney Diseases at the National Institutes of Health may help researchers leverage massive amounts of genomic data to develop…
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How to make a motor neuron Mechanisms underlying direct programming of stem cells could eventually lead to cell-replacement therapies Sam Sholtis December 8, 2016 UNIVERSITY PARK, Pa. — A team of scientists has uncovered details of the cellular mechanisms that control the direct programming of stem cells into motor neurons. The scientists analyzed changes that…
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November 28, 2016 – Lila is a third year graduate student in Dr. Shaun Mahony’s lab. This week she presented her work aimed at 3-D genome reconstruction from kilo base-pair resolution Hi-C data. The knowledge of a three-dimensional chromatin structure is important for studying many biological processes at the molecular level such as transcription regulation,…
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2016 CEGR Fall Retreat Every year, the PIs leading the labs in The Center for Eukaryotic Gene Regulation (CEGR) invite their staff and families to a Fall retreat. Our faculty host a Center-wide activity outside of normal collaborative lab work and the Megameeting on Tuesdays. This year’s event will be hosted at the Civil Engineering Lodge on Lake…
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August 30, 2016 – Ribosomal Protein (RP) genes are co-regulated in the genome, under the control of multiple regulators: Rap1, Fhl1, Ifh1, Sfp1, and Hmo1. A majority of RP genes contain a Rap1 motif upstream of the TSS. It has been shown that Rap1 acts as a master regulator, recruiting other TFs to mediate RPG regulation….
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Eberly Office for Innovation aids tech transfer partnerships Tara Immel June 10, 2016 Across the University, researchers are continually making discoveries and creating inventions that can have real-world impact and societal benefits. Although this intellectual property (IP) and innovation often can result in improving health, developing new materials, and addressing environmental issues, among other important…
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Discovered: How to unlock inaccessible genes 29 January 2016 It was known that the DNA in cells is wrapped around proteins in structures called nucleosomes that resemble beads on a string, which allow the genetic material to be folded and compacted into a structure called chromatin. “We knew that the compaction into chromatin makes genes…
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Seven Penn State Researchers named AAAS Fellows By A’ndrea Elyse Messer November 30, 2015 UNIVERSITY PARK, Pa. — Seven Penn State faculty members have been named Fellows of the American Association for the Advancement of Science, the organization announced November 23, 2015. The 2015 Fellows are Leonard S. Jefferson, Evan Pugh University Professor in Physiology;…
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New approach discovered for brain repair Chemical transformation of human glial cells into neurons Barbara K. Kennedy October 26, 2015 UNIVERSITY PARK, Pa. — For the first time, researchers have used a cocktail of small molecules to transform human brain cells, called astroglial cells, into functioning neurons for brain repair. Their results provide proof-of-principle that…
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2015 CEGR Fall Retreat Every year, the PIs leading the labs in The Center for Eukaryotic Gene Regulation (CEGR) invite their staff and families to a Fall retreat. Our faculty host a Center-wide activity outside of normal collaborative lab work and the Megameeting on Tuesdays. This year’s event will be hosted at Shaver’s Creek on Friday, October 16th…
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