About Us

The CEGR is composed of ten laboratories with over 70 students and staff. We aim to provide a conducive learning environment for making cutting edge discoveries on fundamental mechanisms of eukaryotic gene regulation. Most labs share common space to promote a community of interactions.

Whole CEGR Staff

Academic Environment

The research interests of all CEGR members are focused on understanding the mechanisms of gene regulation, although each member brings unique perspectives and expertise. The members of the Center for Eukaryotic Gene Regulation include:

 

Jean-Paul Armache Ph.D. Cryo-EM structural studies of ATP-dependent chromatin remodelers and other macromolecular machines
Assistant Professor of Biochemistry and Molecular Biology

 

Lu Bai Ph.D. Single cell and single molecule studies of chromatin and gene regulation
Associate Professor of Biochemistry and Molecular Biology
Associate Professor of Physics

 

David Gilmour Ph.D. Transcriptional regulation of the hsp70 heat shock gene in Drosophila
Professor of Molecular and Cell Biology and
Graduate Education Co-Director

 

Ross Hardison Ph.D. Genomics and gene regulation
T. Ming Chu Professor of Biochemistry and Molecular Biology

 

Manuel Llinás Ph.D. — Gene regulation in Plasmodium
Professor of Biochemistry and Molecular Biology

 

Shaun Mahony Ph.D. Computational biology and regulatory genomics
Assistant Professor of Biochemistry & Molecular Biology

 

B. Franklin Pugh Ph.D. Biochemistry and genomics and eukaryotic transcription regulation
Evan Pugh University Professor
Willaman Chair in Molecular Biology and
Professor of Biochemistry and Molecular Biology

 

Joseph Reese Ph.D.Chromatin structure and gene expression, DNA damage resistance pathways
Professor of Biochemistry and Molecular Biology

 

Scott Showalter Ph.D. — Structural biology of transcription regulatory proteins in β-cells
Professor of Chemistry
Professor of Biochemistry and Molecular Biology

 

Song Tan Ph.D.Structural biology of eukaryotic chromatin and gene regulatory proteins
Professor of Biochemistry and Molecular Biology

 

Many CEGR members are located in newly renovated adjoining laboratories on the 4th floor of the North and South Frear buildings. All attend a weekly CEGR research forum (held continuously at Penn State since 1989) where the latest scientific work of our graduate students and postdocs are shared and discussed. The CEGR also hosts international summer symposia on chromatin every four years.  Our most recent symposium occurred in July 2015 and July 2011, attracting approximately 300 participants each time. This closely collaborative research center is therefore a unique and productive environment in which to study the mechanisms of gene regulation.  The next summer symposium will occur on July 30 – August 2, 2019.  The 38th symposium will be on “Chromatin and Epigenetic Regulation of Chromatin”.

 

The Department of Biochemistry and Molecular Biology at Penn State is well known as a center of excellence in genomics research and the development of high-throughput experimental assays and associated computational analysis systems. Other relevant faculty in the department include Prof. Anton Nekrutenko (developer of the Galaxy system for processing experimental data online), and Dr. Paul Medvedev (genome assembly).

 

Interim Director

Song Tan
468A North Frear Laboratory
Penn State University, University Park, PA 16802

814-863-8594